Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Members of the TMEM16/ANO family of membrane proteins are Ca
2+
-activated phospholipid scramblases and/or Cl
−
channels. A membrane-exposed hydrophilic groove in these proteins serves as a shared translocation pathway for ions and lipids. However, the mechanism by which lipids gain access to and permeate through the groove remains poor...
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Full title
Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
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TN_cdi_doaj_primary_oai_doaj_org_article_ae6b3950bcc946ad841e6d949d6d90e5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ae6b3950bcc946ad841e6d949d6d90e5
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05724-1
