Generation of Rhesus Macaque Embryos with Expanded CAG Trinucleotide Repeats in the Huntingtin Gene
Generation of Rhesus Macaque Embryos with Expanded CAG Trinucleotide Repeats in the Huntingtin Gene
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Publisher
Switzerland: MDPI AG
Journal title
Language
English
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Publication information
Publisher
Switzerland: MDPI AG
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Scope and Contents
Contents
Huntington's disease (HD) arises from expanded CAG repeats in exon 1 of the
(
) gene. The resultant misfolded HTT protein accumulates within neuronal cells, negatively impacting their function and survival. Ultimately, HTT accumulation results in cell death, causing the development of HD. A nonhuman primate (NHP) HD model would provide import...
Alternative Titles
Full title
Generation of Rhesus Macaque Embryos with Expanded CAG Trinucleotide Repeats in the Huntingtin Gene
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TN_cdi_doaj_primary_oai_doaj_org_article_aeabb05c2b7e4242af4b9567dccbd292
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_aeabb05c2b7e4242af4b9567dccbd292
Other Identifiers
ISSN
2073-4409
E-ISSN
2073-4409
DOI
10.3390/cells13100829
