Standard screening methods underreport AAV-mediated transduction and gene editing
Standard screening methods underreport AAV-mediated transduction and gene editing
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Conventional methods to discern adeno-associated virus (AAV) vector transduction patterns are based on high, stable expression of a reporter gene. As a consequence, conventionally described tropisms omit cell types that undergo transient transduction, or have low but undetectable levels of reporter expression. This creates a blind spot for AAV-base...
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Standard screening methods underreport AAV-mediated transduction and gene editing
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TN_cdi_doaj_primary_oai_doaj_org_article_af6cb7bdc8fb4782a4723ed186a60397
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_af6cb7bdc8fb4782a4723ed186a60397
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11321-7
