PPIA dictates NRF2 stability to promote lung cancer progression
PPIA dictates NRF2 stability to promote lung cancer progression
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Author / Creator
Lu, Weiqiang , Cui, Jiayan , Wang, Wanyan , Hu, Qian , Xue, Yun , Liu, Xi , Gong, Ting , Lu, Yiping , Ma, Hui , Yang, Xinyu , Feng, Bo , Wang, Qi , Zhang, Naixia , Xu, Yechun , Liu, Mingyao , Nussinov, Ruth , Cheng, Feixiong , Ji, Hongbin and Huang, Jin
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Nuclear factor erythroid 2-related factor 2 (NRF2) hyperactivation has been established as an oncogenic driver in a variety of human cancers, including non-small cell lung cancer (NSCLC). However, despite massive efforts, no specific therapy is currently available to target NRF2 hyperactivation. Here, we identify peptidylprolyl isomerase A (PPIA) i...
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PPIA dictates NRF2 stability to promote lung cancer progression
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TN_cdi_doaj_primary_oai_doaj_org_article_b1e603ba071b4aff88a7aa6440544c4d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b1e603ba071b4aff88a7aa6440544c4d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-48364-4
