A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain
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Author / Creator
Joglekar, Anoushka , Prjibelski, Andrey , Mahfouz, Ahmed , Collier, Paul , Lin, Susan , Schlusche, Anna Katharina , Marrocco, Jordan , Williams, Stephen R. , Haase, Bettina , Hayes, Ashley , Chew, Jennifer G. , Weisenfeld, Neil I. , Wong, Man Ying , Stein, Alexander N. , Hardwick, Simon A. , Hunt, Toby , Wang, Qi , Dieterich, Christoph , Bent, Zachary , Fedrigo, Olivier , Sloan, Steven A. , Risso, Davide , Jarvis, Erich D. , Flicek, Paul , Luo, Wenjie , Pitt, Geoffrey S. , Frankish, Adam , Smit, August B. , Ross, M. Elizabeth and Tilgner, Hagen U.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Splicing varies across brain regions, but the single-cell resolution of regional variation is unclear. We present a single-cell investigation of differential isoform expression (DIE) between brain regions using single-cell long-read sequencing in mouse hippocampus and prefrontal cortex in 45 cell types at postnatal day 7 (
www.isoformAtlas.com
). Isoform tests for DIE show better performance than exon tests. We detect hundreds of DIE events traceable to cell types, often corresponding to functionally distinct protein isoforms. Mostly, one cell type is responsible for brain-region specific DIE. However, for fewer genes, multiple cell types influence DIE. Thus, regional identity ca...
Alternative Titles
Full title
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain
Authors, Artists and Contributors
Author / Creator
Prjibelski, Andrey
Mahfouz, Ahmed
Collier, Paul
Lin, Susan
Schlusche, Anna Katharina
Marrocco, Jordan
Williams, Stephen R.
Haase, Bettina
Hayes, Ashley
Chew, Jennifer G.
Weisenfeld, Neil I.
Wong, Man Ying
Stein, Alexander N.
Hardwick, Simon A.
Hunt, Toby
Wang, Qi
Dieterich, Christoph
Bent, Zachary
Fedrigo, Olivier
Sloan, Steven A.
Risso, Davide
Jarvis, Erich D.
Flicek, Paul
Luo, Wenjie
Pitt, Geoffrey S.
Frankish, Adam
Smit, August B.
Ross, M. Elizabeth
Tilgner, Hagen U.
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Primary Identifiers
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TN_cdi_doaj_primary_oai_doaj_org_article_b27a2afb47544e009093959c837b41e3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b27a2afb47544e009093959c837b41e3
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-20343-5
