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Metabolomic analyses uncover an inhibitory effect of niclosamide on mitochondrial membrane potential...

Metabolomic analyses uncover an inhibitory effect of niclosamide on mitochondrial membrane potential...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b3670b10c86940cf978c7d275eec5e82

Metabolomic analyses uncover an inhibitory effect of niclosamide on mitochondrial membrane potential in cholangiocarcinoma cells

About this item

Full title

Metabolomic analyses uncover an inhibitory effect of niclosamide on mitochondrial membrane potential in cholangiocarcinoma cells

Publisher

San Diego: PeerJ. Ltd

Journal title

PeerJ (San Francisco, CA), 2023-11, Vol.11, p.e16512-e16512, Article e16512

Language

English

Formats

Publication information

Publisher

San Diego: PeerJ. Ltd

More information

Scope and Contents

Contents

Background Niclosamide is an oral anthelminthic drug that has been used for treating tapeworm infections. Its mechanism involves the disturbance of mitochondrial membrane potential that in turn inhibits oxidative phosphorylation leading to ATP depletion. To date, niclosamide has been validated as the potent anti-cancer agent against several cancers...

Alternative Titles

Full title

Metabolomic analyses uncover an inhibitory effect of niclosamide on mitochondrial membrane potential in cholangiocarcinoma cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_b3670b10c86940cf978c7d275eec5e82

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b3670b10c86940cf978c7d275eec5e82

Other Identifiers

ISSN

2167-8359

E-ISSN

2167-8359

DOI

10.7717/peerj.16512

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