An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell r...
An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor
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Publisher
England: eLife Sciences Publications Ltd
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Language
English
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England: eLife Sciences Publications Ltd
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Contents
The sequence of events that initiates T cell signaling is dictated by the specificities and order of activation of the tyrosine kinases that signal downstream of the T cell receptor. Using a platform that combines exhaustive point-mutagenesis of peptide substrates, bacterial surface-display, cell sorting, and deep sequencing, we have defined the sp...
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Full title
An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor
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TN_cdi_doaj_primary_oai_doaj_org_article_b39beca68cc0453aa3b66feed4aec35e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b39beca68cc0453aa3b66feed4aec35e
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.20105
