Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry
Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry
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Author / Creator
Leonhardt, Susan A. , Purdy, Michael D. , Grover, Jonathan R. , Yang, Ziwei , Poulos, Sandra , McIntire, William E. , Tatham, Elizabeth A. , Erramilli, Satchal K. , Nosol, Kamil , Lai, Kin Kui , Ding, Shilei , Lu, Maolin , Uchil, Pradeep D. , Finzi, Andrés , Rein, Alan , Kossiakoff, Anthony A. , Mothes, Walther and Yeager, Mark
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates incorporation of SERINCs via binding to intracellular loop 4 (ICL4). Here, we determine cryoEM maps of full-length human SERINC3 and an ICL4 deletion construct, which reveal...
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Full title
Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry
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TN_cdi_doaj_primary_oai_doaj_org_article_b42d4618236b4cabb367d4bb3ff2f26d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b42d4618236b4cabb367d4bb3ff2f26d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-39262-2
