Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme com...
Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex
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Author / Creator
Gauto, Diego F. , Estrozi, Leandro F. , Schwieters, Charles D. , Effantin, Gregory , Macek, Pavel , Sounier, Remy , Sivertsen, Astrid C. , Schmidt, Elena , Kerfah, Rime , Mas, Guillaume , Colletier, Jacques-Philippe , Güntert, Peter , Favier, Adrien , Schoehn, Guy , Schanda, Paul and Boisbouvier, Jerome
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Atomic-resolution structure determination is crucial for understanding protein function. Cryo-EM and NMR spectroscopy both provide structural information, but currently cryo-EM does not routinely give access to atomic-level structural data, and, generally, NMR structure determination is restricted to small (<30 kDa) proteins. We introduce an integr...
Alternative Titles
Full title
Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b46e113a51c845d98317d17073be2ebe
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b46e113a51c845d98317d17073be2ebe
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10490-9
