Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer tr...
Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer treated with a combination of the PI3K inhibitor alpelisib (BYL719) and fulvestrant
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Author / Creator
Jacquemetton, Julien , Kassem, Loay , Poulard, Coralie , Dahmani, Ahmed , De Plater, Ludmilla , Montaudon, Elodie , Sourd, Laura , Morisset, Ludivine , El Botty, Rania , Chateau-Joubert, Sophie , Vacher, Sophie , Bièche, Ivan , Treilleux, Isabelle , Trédan, Olivier , Marangoni, Elisabetta and Le Romancer, Muriel
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Endocrine therapies targeting estrogen signaling have significantly improved breast cancer (BC) patient survival, although 40% of ERα-positive BCs do not respond to those therapies. Aside from genomic signaling, estrogen triggers non-genomic pathways by forming a complex containing methylERα/Src/PI3K, a hallmark of aggressiveness and resistance to...
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Full title
Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer treated with a combination of the PI3K inhibitor alpelisib (BYL719) and fulvestrant
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TN_cdi_doaj_primary_oai_doaj_org_article_b4f002221c8e4979bfc49c690736c595
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b4f002221c8e4979bfc49c690736c595
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ISSN
1465-542X,1465-5411
E-ISSN
1465-542X
DOI
10.1186/s13058-021-01433-8
