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ArticlesPeer ReviewedFull Text
Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 tr...
Author / Creator:Le Tourneau, Christophe, Dr ; Delord, Jean-Pierre, Prof ; Gonçalves, Anthony, Prof ; Gavoille, Céline, MD ; Dubot, Coraline, MD ; Isambert, Nicolas, MD ; Campone, Mario, Prof ; Trédan, Olivier, MD ; Massiani, Marie-Ange, MD ; Mauborgne, Cécile, MSc ; Armanet, Sebastien, MSc ; Servant, Nicolas, PhD ; Bièche, Ivan, PhD ; Bernard, Virginie, PhD ; Gentien, David, PhD ; Jezequel, Pascal, MD ; Attignon, Valéry, PhD ; Boyault, Sandrine, PhD ; Vincent-Salomon, Anne, MD ; Servois, Vincent, MD ; Sablin, Marie-Paule, MD ; Kamal, Maud, PhD ; Paoletti, Xavier, PhD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2015-10, Vol.16 (13), p.1324-1334
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Cortical branched actin determines cell cycle progression
Author / Creator:Molinie, Nicolas ; Rubtsova, Svetlana N. ; Fokin, Artem ; Visweshwaran, Sai P. ; Rocques, Nathalie ; Polesskaya, Anna ; Schnitzler, Anne ; Vacher, Sophie ; Denisov, Evgeny V. ; Tashireva, Lubov A. ; Perelmuter, Vladimir M. ; Cherdyntseva, Nadezhda V. ; Bièche, Ivan ; Gautreau, Alexis M.
Publisher:London: Nature Publishing Group UK
Journal title:Cell research, 2019-06, Vol.29 (6), p.432-445
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Circulating tumor DNA as a dynamic biomarker of response to palbociclib and fulvestrant in metastatic breast cancer patients
Author / Creator:Darrigues, Lauren ; Pierga, Jean-Yves ; Bernard-Tessier, Alice ; Bièche, Ivan ; Silveira, Amanda Bartolini ; Michel, Marc ; Loirat, Delphine ; Cottu, Paul ; Cabel, Luc ; Dubot, Coraline ; Geiss, Romain ; Ricci, Francesco ; Vincent-Salomon, Anne ; Proudhon, Charlotte ; Bidard, François-Clément
Publisher:England: BioMed Central Ltd
Journal title:Breast cancer research : BCR, 2021-03, Vol.23 (1), p.31-31, Article 31
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Oxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
Author / Creator:El-Botty, Rania ; Morriset, Ludivine ; Montaudon, Elodie ; Tariq, Zakia ; Schnitzler, Anne ; Bacci, Marina ; Lorito, Nicla ; Sourd, Laura ; Huguet, Léa ; Dahmani, Ahmed ; Painsec, Pierre ; Derrien, Heloise ; Vacher, Sophie ; Masliah-Planchon, Julien ; Raynal, Virginie ; Baulande, Sylvain ; Larcher, Thibaut ; Vincent-Salomon, Anne ; Dutertre, Guillaume ; Cottu, Paul ; Gentric, Géraldine ; Mechta-Grigoriou, Fatima ; Hutton, Scott ; Driouch, Keltouma ; Bièche, Ivan ; Morandi, Andrea ; Marangoni, Elisabetta
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-07, Vol.14 (1), p.4221-4221, Article 4221
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Homologous recombination deficiency derived from whole-genome sequencing predicts platinum response in triple-negative breast cancers
Author / Creator:ter Brugge, Petra ; Moser, Sarah C. ; Bièche, Ivan ; Kristel, Petra ; Ibadioune, Sabrina ; Eeckhoutte, Alexandre ; de Bruijn, Roebi ; van der Burg, Eline ; Lutz, Catrin ; Annunziato, Stefano ; de Ruiter, Julian ; Masliah Planchon, Julien ; Vacher, Sophie ; Courtois, Laura ; El-Botty, Rania ; Dahmani, Ahmed ; Montaudon, Elodie ; Morisset, Ludivine ; Sourd, Laura ; Huguet, Léa ; Derrien, Heloise ; Nemati, Fariba ; Chateau-Joubert, Sophie ; Larcher, Thibaut ; Salomon, Anne ; Decaudin, Didier ; Reyal, Fabien ; Coussy, Florence ; Popova, Tatiana ; Wesseling, Jelle ; Stern, Marc-Henri ; Jonkers, Jos ; Marangoni, Elisabetta
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-04, Vol.14 (1), p.1958-1958, Article 1958
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BCG therapy downregulates HLA-I on malignant cells to subvert antitumor immune responses in bladder cancer
Author / Creator:Rouanne, Mathieu ; Adam, Julien ; Radulescu, Camélia ; Letourneur, Diane ; Bredel, Delphine ; Mouraud, Séverine ; Goubet, Anne-Gaëlle ; Leduc, Marion ; Chen, Noah ; Tan, Tuan Zea ; Signolle, Nicolas ; Bigorgne, Amélie ; Dussiot, Michael ; Tselikas, Lambros ; Susini, Sandrine ; Danlos, François-Xavier ; Schneider, Anna K. ; Chabanon, Roman ; Vacher, Sophie ; Bièche, Ivan ; Lebret, Thierry ; Allory, Yves ; Soria, Jean-Charles ; Arpaia, Nicholas ; Kroemer, Guido ; Kepp, Oliver ; Thiery, Jean Paul ; Zitvogel, Laurence ; Marabelle, Aurélien
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2022-06, Vol.132 (12), p.1-17
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ArticlesPeer ReviewedFull Text
Genome-wide methylation analyses identifies Non-coding RNA genes dysregulated in breast tumours that metastasise to the brain
Author / Creator:Pangeni, Rajendra P. ; Olivaries, Ivonne ; Huen, David ; Buzatto, Vannessa C. ; Dawson, Timothy P. ; Ashton, Katherine M. ; Davis, Charles ; Brodbelt, Andrew R. ; Jenkinson, Michael D. ; Bièche, Ivan ; Yang, Lu ; Latif, Farida ; Darling, John L. ; Warr, Tracy J. ; Morris, Mark R.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-01, Vol.12 (1), p.1102-1102, Article 1102
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ArticlesPeer ReviewedFull Text
Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut
Author / Creator:Chanrion, Maia ; Kuperstein, Inna ; Barrière, Cédric ; El Marjou, Fatima ; Cohen, David ; Vignjevic, Danijela ; Stimmer, Lev ; Paul-Gilloteaux, Perrine ; Bièche, Ivan ; Tavares, Silvina Dos Reis ; Boccia, Giuseppe-Fulvio ; Cacheux, Wulfran ; Meseure, Didier ; Fre, Silvia ; Martignetti, Loredana ; Legoix-Né, Patricia ; Girard, Elodie ; Fetler, Luc ; Barillot, Emmanuel ; Louvard, Daniel ; Zinovyev, Andreï ; Robine, Sylvie
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2014-10, Vol.5 (1), p.5005-5005, Article 5005
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ArticlesPeer ReviewedFull Text
PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance
Author / Creator:Montaudon, Elodie ; Nikitorowicz-Buniak, Joanna ; Sourd, Laura ; Morisset, Ludivine ; El Botty, Rania ; Huguet, Léa ; Dahmani, Ahmed ; Painsec, Pierre ; Nemati, Fariba ; Vacher, Sophie ; Chemlali, Walid ; Masliah-Planchon, Julien ; Château-Joubert, Sophie ; Rega, Camilla ; Leal, Mariana Ferreira ; Simigdala, Nikiana ; Pancholi, Sunil ; Ribas, Ricardo ; Nicolas, André ; Meseure, Didier ; Vincent-Salomon, Anne ; Reyes, Cécile ; Rapinat, Audrey ; Gentien, David ; Larcher, Thibaut ; Bohec, Mylène ; Baulande, Sylvain ; Bernard, Virginie ; Decaudin, Didier ; Coussy, Florence ; Le Romancer, Muriel ; Dutertre, Guillaume ; Tariq, Zakia ; Cottu, Paul ; Driouch, Keltouma ; Bièche, Ivan ; Martin, Lesley-Ann ; Marangoni, Elisabetta
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-08, Vol.11 (1), p.4053-4053, Article 4053
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ArticlesPeer ReviewedFull Text
PIK3R1 underexpression is an independent prognostic marker in breast cancer
Author / Creator:Cizkova, Magdalena ; Vacher, Sophie ; Meseure, Didier ; Trassard, Martine ; Susini, Aurélie ; Mlcuchova, Dana ; Callens, Celine ; Rouleau, Etienne ; Spyratos, Frederique ; Lidereau, Rosette ; Bièche, Ivan
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2013-11, Vol.13 (1), p.545-545, Article 545
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ArticlesPeer ReviewedFull Text
Cellular origin and clonal evolution of human dedifferentiated liposarcoma
Author / Creator:Gruel, Nadège ; Quignot, Chloé ; Lesage, Laëtitia ; El Zein, Sophie ; Bonvalot, Sylvie ; Tzanis, Dimitri ; Ait Rais, Khadija ; Quinquis, Fabien ; Manciot, Bastien ; Vibert, Julien ; El Tannir, Nadine ; Dahmani, Ahmed ; Derrien, Héloïse ; Decaudin, Didier ; Bièche, Ivan ; Courtois, Laura ; Mariani, Odette ; Linares, Laëtitia K. ; Gayte, Laurie ; Baulande, Sylvain ; Waterfall, Joshua J. ; Delattre, Olivier ; Pierron, Gaëlle ; Watson, Sarah
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-09, Vol.15 (1), p.7941-18, Article 7941
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Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer treated with a combination of the PI3K inhibitor alpelisib (BYL719) and fulvestrant
Author / Creator:Jacquemetton, Julien ; Kassem, Loay ; Poulard, Coralie ; Dahmani, Ahmed ; De Plater, Ludmilla ; Montaudon, Elodie ; Sourd, Laura ; Morisset, Ludivine ; El Botty, Rania ; Chateau-Joubert, Sophie ; Vacher, Sophie ; Bièche, Ivan ; Treilleux, Isabelle ; Trédan, Olivier ; Marangoni, Elisabetta ; Le Romancer, Muriel
Publisher:England: BioMed Central Ltd
Journal title:Breast cancer research : BCR, 2021-05, Vol.23 (1), p.57-57, Article 57
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The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor
Author / Creator:Lacombe, Marie-Lise ; Lamarche, Frederic ; De Wever, Olivier ; Padilla-Benavides, Teresita ; Carlson, Alyssa ; Khan, Imran ; Huna, Anda ; Vacher, Sophie ; Calmel, Claire ; Desbourdes, Céline ; Cottet-Rousselle, Cécile ; Hininger-Favier, Isabelle ; Attia, Stéphane ; Nawrocki-Raby, Béatrice ; Raingeaud, Joël ; Machon, Christelle ; Guitton, Jérôme ; Le Gall, Morgane ; Clary, Guilhem ; Broussard, Cedric ; Chafey, Philippe ; Thérond, Patrice ; Bernard, David ; Fontaine, Eric ; Tokarska-Schlattner, Malgorzata ; Steeg, Patricia ; Bièche, Ivan ; Schlattner, Uwe ; Boissan, Mathieu
Publisher:England: BioMed Central Ltd
Journal title:BMC biology, 2021-10, Vol.19 (1), p.228-228, Article 228
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Control of MT1-MMP transport by atypical PKC during breast-cancer progression
Author / Creator:Rossé, Carine ; Lodillinsky, Catalina ; Fuhrmann, Laetitia ; Nourieh, Maya ; Monteiro, Pedro ; Irondelle, Marie ; Lagoutte, Emilie ; Vacher, Sophie ; Waharte, François ; Paul-Gilloteaux, Perrine ; Romao, Maryse ; Sengmanivong, Lucie ; Linch, Mark ; van Lint, Johan ; Raposo, Graça ; Vincent-Salomon, Anne ; Bièche, Ivan ; Parker, Peter J. ; Chavrier, Philippe
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-05, Vol.111 (18), p.E1872-E1879
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Tumor mutational burden assessment and standardized bioinformatics approach using custom NGS panels in clinical routine
Author / Creator:Dupain, Célia ; Gutman, Tom ; Girard, Elodie ; Kamoun, Choumouss ; Marret, Grégoire ; Castel-Ajgal, Zahra ; Sablin, Marie-Paule ; Neuzillet, Cindy ; Borcoman, Edith ; Hescot, Ségolène ; Callens, Céline ; Trabelsi-Grati, Olfa ; Melaabi, Samia ; Vibert, Roseline ; Antonio, Samantha ; Franck, Coralie ; Galut, Michèle ; Guillou, Isabelle ; Halladjian, Maral ; Allory, Yves ; Cyrta, Joanna ; Romejon, Julien ; Frouin, Eleonore ; Stoppa-Lyonnet, Dominique ; Wong, Jennifer ; Le Tourneau, Christophe ; Bièche, Ivan ; Servant, Nicolas ; Kamal, Maud ; Masliah-Planchon, Julien
Publisher:England: BioMed Central Ltd
Journal title:BMC biology, 2024-02, Vol.22 (1), p.43-43, Article 43
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Randomized phase II study of preoperative afatinib in untreated head and neck cancers: predictive and pharmacodynamic biomarkers of activity
Author / Creator:Marret, Grégoire ; Temam, Stéphane ; Kamal, Maud ; Even, Caroline ; Delord, Jean-Pierre ; Hoffmann, Caroline ; Dolivet, Gilles ; Malard, Olivier ; Fayette, Jérôme ; Capitain, Olivier ; Vergez, Sébastien ; Geoffrois, Lionel ; Rolland, Frédéric ; Zrounba, Philippe ; Laccourreye, Laurent ; Saada-Bouzid, Esma ; Aide, Nicolas ; Bénavent, Valérie ; Klijianenko, Jerzy ; Lamy, Constance ; Girard, Elodie ; Vacher, Sophie ; Masliah-Planchon, Julien ; de Koning, Leanne ; Puard, Vincent ; Borcoman, Edith ; Jimenez, Marta ; Bièche, Ivan ; Gal, Jocelyn ; Le Tourneau, Christophe
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-12, Vol.13 (1), p.22524-22524, Article 22524
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Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis
Author / Creator:Shackleford, Ghjuvan’Ghjacumu ; Sampathkumar, Nirmal Kumar ; Hichor, Mehdi ; Weill, Laure ; Meffre, Delphine ; Juricek, Ludmila ; Laurendeau, Ingrid ; Chevallier, Aline ; Ortonne, Nicolas ; Larousserie, Frédérique ; Herbin, Marc ; Bièche, Ivan ; Coumoul, Xavier ; Beraneck, Mathieu ; Baulieu, Etienne-Emile ; Charbonnier, Frédéric ; Pasmant, Eric ; Massaad, Charbel
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-02, Vol.115 (6), p.E1319-E1328
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HORMAD1 overexpression predicts response to anthracycline–cyclophosphamide and survival in triple‐negative breast cancers
Author / Creator:El‐Botty, Rania ; Vacher, Sophie ; Mainguené, Juliette ; Briaux, Adrien ; Ibadioune, Sabrina ; Dahmani, Ahmed ; Montaudon, Elodie ; Nemati, Fariba ; Huguet, Léa ; Sourd, Laura ; Morriset, Ludivine ; Château‐Joubert, Sophie ; Dubois, Thierry ; Maire, Virginie ; Lidereau, Rosette ; Rapinat, Audrey ; Gentien, David ; Coussy, Florence ; Bièche, Ivan ; Marangoni, Elisabetta
Publisher:United States: John Wiley & Sons, Inc
Journal title:Molecular oncology, 2023-10, Vol.17 (10), p.2017-2028
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Human papilloma virus integration sites and genomic signatures in head and neck squamous cell carcinoma
Author / Creator:Mainguené, Juliette ; Vacher, Sophie ; Kamal, Maud ; Hamza, Abderaouf ; Masliah‐Planchon, Julien ; Baulande, Sylvain ; Ibadioune, Sabrina ; Borcoman, Edith ; Cacheux, Wulfran ; Calugaru, Valentin ; Courtois, Laura ; Crozes, Carole ; Deloger, Marc ; Girard, Elodie ; Delord, Jean‐Pierre ; Dubray‐Vautrin, Antoine ; Larbi Chérif, Linda ; Dupain, Celia ; Jeannot, Emmanuelle ; Klijanienko, Jerzy ; Lameiras, Sonia ; Lecerf, Charlotte ; Modesto, Anouchka ; Nicolas, Alain ; Rouzier, Roman ; Saada‐Bouzid, Esma ; Saintigny, Pierre ; Sudaka, Anne ; Servant, Nicolas ; Le Tourneau, Christophe ; Bièche, Ivan
Publisher:United States: John Wiley & Sons, Inc
Journal title:Molecular oncology, 2022-08, Vol.16 (16), p.3001-3016
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Molecular features of untreated breast cancer and initial metastatic event inform clinical decision-making and predict outcome: long-term results of ESOPE, a single-arm prospective multicenter study
Author / Creator:Callens, Céline ; Driouch, Keltouma ; Boulai, Anaïs ; Tariq, Zakia ; Comte, Aurélie ; Berger, Frédérique ; Belin, Lisa ; Bièche, Ivan ; Servois, Vincent ; Legoix, Patricia ; Bernard, Virginie ; Baulande, Sylvain ; Chemlali, Walid ; Bidard, François-Clément ; Fourchotte, Virginie ; Salomon, Anne Vincent ; Brain, Etienne ; Lidereau, Rosette ; Bachelot, Thomas ; Saghatchian, Mahasti ; Campone, Mario ; Giacchetti, Sylvie ; Zafrani, Brigitte Sigal ; Cottu, Paul
Publisher:England: BioMed Central Ltd
Journal title:Genome medicine, 2021-03, Vol.13 (1), p.44-44, Article 44
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Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 tr...

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Cortical branched actin determines cell cycle progression

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Circulating tumor DNA as a dynamic biomarker of response to palbociclib and fulvestrant in metastatic breast cancer patients

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Oxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers

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Homologous recombination deficiency derived from whole-genome sequencing predicts platinum response in triple-negative breast cancers

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BCG therapy downregulates HLA-I on malignant cells to subvert antitumor immune responses in bladder cancer

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Genome-wide methylation analyses identifies Non-coding RNA genes dysregulated in breast tumours that metastasise to the brain

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Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut

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PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance

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PIK3R1 underexpression is an independent prognostic marker in breast cancer

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Cellular origin and clonal evolution of human dedifferentiated liposarcoma

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Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer treated with a combination of the PI3K inhibitor alpelisib (BYL719) and fulvestrant

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The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor

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Control of MT1-MMP transport by atypical PKC during breast-cancer progression

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Tumor mutational burden assessment and standardized bioinformatics approach using custom NGS panels in clinical routine

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Randomized phase II study of preoperative afatinib in untreated head and neck cancers: predictive and pharmacodynamic biomarkers of activity

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Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis

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HORMAD1 overexpression predicts response to anthracycline–cyclophosphamide and survival in triple‐negative breast cancers

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Human papilloma virus integration sites and genomic signatures in head and neck squamous cell carcinoma

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Molecular features of untreated breast cancer and initial metastatic event inform clinical decision-making and predict outcome: long-term results of ESOPE, a single-arm prospective multicenter study

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