Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacy...
Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive subtype of acute leukemia, the cell of origin of which is considered to be precursors of plasmacytoid dendritic cells (pDCs). Since translocation (6;8)(p21;q24) is a recurrent anomaly for BPDCN, we demonstrate that a pDC-specific super-enhancer of
RUNX2
is associated with t...
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Full title
Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm
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TN_cdi_doaj_primary_oai_doaj_org_article_b55f6237adba4583b97db796afe3c64f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b55f6237adba4583b97db796afe3c64f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09710-z
