Impact of age and vector construct on striatal and nigral transgene expression
Impact of age and vector construct on striatal and nigral transgene expression
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Publisher
United States: Elsevier Limited
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Language
English
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Publisher
United States: Elsevier Limited
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Contents
Therapeutic protein delivery using viral vectors has shown promise in preclinical models of Parkinson's disease (PD) but clinical trial success remains elusive. This may partially be due to a failure to include advanced age as a covariate despite aging being the primary risk factor for PD. We investigated transgene expression following intracerebra...
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Full title
Impact of age and vector construct on striatal and nigral transgene expression
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TN_cdi_doaj_primary_oai_doaj_org_article_b5c21ac0c35c4056a4ceb135f2ad599d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b5c21ac0c35c4056a4ceb135f2ad599d
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ISSN
2329-0501
E-ISSN
2329-0501
DOI
10.1038/mtm.2016.82
