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Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression

Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b63be19c78e4404ea4ececcfde2c8abb

Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression

About this item

Full title

Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression

Publisher

England: eLife Sciences Publications Ltd

Journal title

eLife, 2020-04, Vol.9

Language

English

Formats

Publication information

Publisher

England: eLife Sciences Publications Ltd

More information

Scope and Contents

Contents

The melanoma-associated antigen family A (MAGEA) antigens are expressed in a wide variety of malignant tumors but not in adult somatic cells, rendering them attractive targets for cancer immunotherapy. Here we show that a number of cancer-associated MAGEA mutants that undergo proteasome-dependent degradation in vitro could negatively impact their u...

Alternative Titles

Full title

Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_b63be19c78e4404ea4ececcfde2c8abb

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b63be19c78e4404ea4ececcfde2c8abb

Other Identifiers

ISSN

2050-084X

E-ISSN

2050-084X

DOI

10.7554/eLife.48963

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