Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian de...
Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
De novo establishment of DNA methylation is accomplished by DNMT3A and DNMT3B. Here, we analyze de novo DNA methylation in mouse embryonic fibroblasts (2i-MEFs) derived from DNA-hypomethylated 2i/L ES cells with genetic ablation of
Dnmt3a
or
Dnmt3b
. We identify 355 and 333 uniquely unmethylated genes in
Dnmt3a
and
Dnmt3b
kn...
Alternative Titles
Full title
Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
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TN_cdi_doaj_primary_oai_doaj_org_article_b65b6e33e3a14ce7b532093c4f2b9276
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b65b6e33e3a14ce7b532093c4f2b9276
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16989-w
