The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-d-Xy...
The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase from Plasmodium falciparum Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying N -Substituents
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Switzerland: MDPI AG
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English
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Switzerland: MDPI AG
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It is established that reverse hydroxamate analogs of fosmidomycin inhibit the growth of
by inhibiting 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR), the second enzyme of the non-mevalonate pathway, which is absent in humans. Recent biochemical studies have demonstrated that novel reverse fosmidomycin analogs with phenylalkyl substituent...
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Full title
The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase from Plasmodium falciparum Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying N -Substituents
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TN_cdi_doaj_primary_oai_doaj_org_article_b674a29f38374344b16d98c95f88e510
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b674a29f38374344b16d98c95f88e510
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules30010072
