The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for subs...
The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Proteins are targeted to the proteasome by the attachment of ubiquitin chains, which are markedly varied in structure. Three proteasome subunits–Rpn10, Rpn13, and Rpn1–can recognize ubiquitin chains. Here we report that proteins with single chains of K48-linked ubiquitin are targeted for degradation almost exclusively through binding to Rpn10. Rpn1...
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Full title
The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates
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TN_cdi_doaj_primary_oai_doaj_org_article_b6829197ab4442dc88d9ed892b9626e3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b6829197ab4442dc88d9ed892b9626e3
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13906-8
