Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antie...
Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Complex tissue-specific and cell-specific signaling by the estrogen receptor (ER) frequently leads to the development of resistance to endocrine therapy for breast cancer. Pure ER antagonists, which completely lack tissue-specific agonist activity, hold promise for preventing and treating endocrine resistance, however an absence of structural infor...
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Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity
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TN_cdi_doaj_primary_oai_doaj_org_article_b6e95950680a407c8d0a86c8da7e1436
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b6e95950680a407c8d0a86c8da7e1436
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04413-3
