MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechan...
MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in many chronic inflammatory diseases, including cardiovascular and Alzheimer’s disease. Here we show that microtubule-affinity regulating kinase 4 (MARK4) binds to NLRP3 and drives it to the microtubule-organizing centre, enabling the formation of one...
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Full title
MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism
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TN_cdi_doaj_primary_oai_doaj_org_article_b75b1e786f494ff79643fc1b0ffb5763
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b75b1e786f494ff79643fc1b0ffb5763
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15986
