Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synoviu...
Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium
About this item
Full title
Author / Creator
Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network , Dunlap, Garrett , Wagner, Aaron , Meednu, Nida , Wang, Ruoqiao , Zhang, Fan , Ekabe, Jabea Cyril , Jonsson, Anna Helena , Wei, Kevin , Sakaue, Saori , Nathan, Aparna , Bykerk, Vivian P. , Donlin, Laura T. , Goodman, Susan M. , Firestein, Gary S. , Boyle, David L. , Holers, V. Michael , Moreland, Larry W. , Tabechian, Darren , Pitzalis, Costantino , Filer, Andrew , Raychaudhuri, Soumya , Brenner, Michael B. , Thakar, Juilee , McDavid, Andrew , Rao, Deepak A. and Anolik, Jennifer H.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify clonally expanded CD4 + T cells, including CCL5+ cells and T peripheral helper (Tph) cells, which show a pro...
Alternative Titles
Full title
Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium
Authors, Artists and Contributors
Author / Creator
Dunlap, Garrett
Wagner, Aaron
Meednu, Nida
Wang, Ruoqiao
Zhang, Fan
Ekabe, Jabea Cyril
Jonsson, Anna Helena
Wei, Kevin
Sakaue, Saori
Nathan, Aparna
Bykerk, Vivian P.
Donlin, Laura T.
Goodman, Susan M.
Firestein, Gary S.
Boyle, David L.
Holers, V. Michael
Moreland, Larry W.
Tabechian, Darren
Pitzalis, Costantino
Filer, Andrew
Raychaudhuri, Soumya
Brenner, Michael B.
Thakar, Juilee
McDavid, Andrew
Rao, Deepak A.
Anolik, Jennifer H.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b76b85a9921847d4919133eeb47ed023
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b76b85a9921847d4919133eeb47ed023
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-49186-0
