X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate rel...
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
About this item
Full title
Author / Creator
Gotfryd, Kamil , Boesen, Thomas , Mortensen, Jonas S. , Khelashvili, George , Quick, Matthias , Terry, Daniel S. , Missel, Julie W. , LeVine, Michael V. , Gourdon, Pontus , Blanchard, Scott C. , Javitch, Jonathan A. , Weinstein, Harel , Loland, Claus J. , Nissen, Poul , Gether, Ulrik , Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States) and Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Neurotransmitter:sodium symporters (NSS) are conserved from bacteria to man and serve as targets for drugs, including antidepressants and psychostimulants. Here we report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na
+
/substrate-bound, inward-facing occluded conformation. To obtain this structure, we were guided by finding...
Alternative Titles
Full title
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
Authors, Artists and Contributors
Author / Creator
Boesen, Thomas
Mortensen, Jonas S.
Khelashvili, George
Quick, Matthias
Terry, Daniel S.
Missel, Julie W.
LeVine, Michael V.
Gourdon, Pontus
Blanchard, Scott C.
Javitch, Jonathan A.
Weinstein, Harel
Loland, Claus J.
Nissen, Poul
Gether, Ulrik
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b7943f31d4e74b9daf78fc8c7d1b60c1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b7943f31d4e74b9daf78fc8c7d1b60c1
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-14735-w
