Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals
Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals
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Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by mutations in
(
). Loss of
causes impaired mitochondrial function and iron homeostasis. An elevated production of reactive oxygen species (ROS) was previously proposed to contribute to the pathogenesis of FRDA. We recently showed that loss of
(
),...
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Full title
Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals
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TN_cdi_doaj_primary_oai_doaj_org_article_b795688a74a048bcb40712b38d7070cf
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b795688a74a048bcb40712b38d7070cf
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.20732
