Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal...
Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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DNA G-quadruplexes are not only attractive drug targets for cancer therapeutics, but also have important applications in supramolecular assembly. Here, we report a platinum(II)-based tripod (Pt-tripod) specifically binds the biological relevant hybrid-1 human telomeric G-quadruplex (Tel26), and strongly inhibits telomerase activity. Further investi...
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Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
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TN_cdi_doaj_primary_oai_doaj_org_article_b86abdb8dcab48ffa099caa1ceb4eeee
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b86abdb8dcab48ffa099caa1ceb4eeee
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05810-4
