Computational design of thermostabilizing point mutations for G protein-coupled receptors
Computational design of thermostabilizing point mutations for G protein-coupled receptors
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England: eLife Sciences Publications, Ltd
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English
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England: eLife Sciences Publications, Ltd
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Engineering of GPCR constructs with improved thermostability is a key for successful structural and biochemical studies of this transmembrane protein family, targeted by 40% of all therapeutic drugs. Here we introduce a comprehensive computational approach to effective prediction of stabilizing mutations in GPCRs, named CompoMug, which employs sequ...
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Full title
Computational design of thermostabilizing point mutations for G protein-coupled receptors
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TN_cdi_doaj_primary_oai_doaj_org_article_b8940c7a6e0345e6acf1ba771959fe13
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b8940c7a6e0345e6acf1ba771959fe13
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.34729
