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ArticlesPeer ReviewedFull Text
Trends in GPCR drug discovery: new agents, targets and indications
Author / Creator:Hauser, Alexander S. ; Attwood, Misty M. ; Rask-Andersen, Mathias ; Schiöth, Helgi B. ; Gloriam, David E.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2017-12, Vol.16 (12), p.829-842
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Selectivity determinants of GPCR–G-protein binding
Author / Creator:Flock, Tilman ; Hauser, Alexander S. ; Lund, Nadia ; Gloriam, David E. ; Balaji, Santhanam ; Babu, M. Madan
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-05, Vol.545 (7654), p.317-322
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Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis
Author / Creator:Cahill, Thomas J. ; Thomsen, Alex R. B. ; Tarrasch, Jeffrey T. ; Plouffe, Bianca ; Nguyen, Anthony H. ; Yang, Fan ; Huang, Li-Yin ; Kahsai, Alem W. ; Bassoni, Daniel L. ; Gavino, Bryant J. ; Lamerdin, Jane E. ; Triest, Sarah ; Shukla, Arun K. ; Berger, Benjamin ; Little, John ; Antar, Albert ; Blanc, Adi ; Qu, Chang-Xiu ; Chen, Xin ; Kawakami, Kouki ; Inoue, Asuka ; Aoki, Junken ; Steyaert, Jan ; Sun, Jin-Peng ; Bouvier, Michel ; Skiniotis, Georgios ; Lefkowitz, Robert J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (10), p.2562-2567
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Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
Author / Creator:Liang, Yi-Lynn ; Khoshouei, Maryam ; Radjainia, Mazdak ; Zhang, Yan ; Glukhova, Alisa ; Tarrasch, Jeffrey ; Thal, David M. ; Furness, Sebastian G. B. ; Christopoulos, George ; Coudrat, Thomas ; Danev, Radostin ; Baumeister, Wolfgang ; Miller, Laurence J. ; Christopoulos, Arthur ; Kobilka, Brian K. ; Wootten, Denise ; Skiniotis, Georgios ; Sexton, Patrick M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-06, Vol.546 (7656), p.118-123
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Structure and dynamics of GPCR signaling complexes
Author / Creator:Hilger, Daniel ; Masureel, Matthieu ; Kobilka, Brian K.
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2018-01, Vol.25 (1), p.4-12
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Conformational biosensors reveal GPCR signalling from endosomes
Author / Creator:Irannejad, Roshanak ; Tomshine, Jin C. ; Tomshine, Jon R. ; Chevalier, Michael ; Mahoney, Jacob P. ; Steyaert, Jan ; Rasmussen, Søren G. F. ; Sunahara, Roger K. ; El-Samad, Hana ; Huang, Bo ; von Zastrow, Mark
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-03, Vol.495 (7442), p.534-538
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Targeting lipid GPCRs to treat type 2 diabetes mellitus — progress and challenges
Author / Creator:Ghislain, Julien ; Poitout, Vincent
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Endocrinology, 2021-03, Vol.17 (3), p.162-175
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GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation
Author / Creator:Drube, J. ; Haider, R. S. ; Matthees, E. S. F. ; Reichel, M. ; Zeiner, J. ; Fritzwanker, S. ; Ziegler, C. ; Barz, S. ; Klement, L. ; Filor, J. ; Weitzel, V. ; Kliewer, A. ; Miess-Tanneberg, E. ; Kostenis, E. ; Schulz, S. ; Hoffmann, C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-01, Vol.13 (1), p.540-540, Article 540
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β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation
Author / Creator:Eichel, K. ; Jullié, D. ; von Zastrow, M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2016-03, Vol.18 (3), p.303-310
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Molecular mechanism of GPCR-mediated arrestin activation
Author / Creator:Latorraca, Naomi R. ; Wang, Jason K. ; Bauer, Brian ; Townshend, Raphael J. L. ; Hollingsworth, Scott A. ; Olivieri, Julia E. ; Xu, H. Eric ; Sommer, Martha E. ; Dror, Ron O.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-05, Vol.557 (7705), p.452-456
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GPCR activation mechanisms across classes and macro/microscales
Author / Creator:Hauser, Alexander S. ; Kooistra, Albert J. ; Munk, Christian ; Heydenreich, Franziska M. ; Veprintsev, Dmitry B. ; Bouvier, Michel ; Babu, M. Madan ; Gloriam, David E.
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2021-11, Vol.28 (11), p.879-888
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Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008
Author / Creator:Michino, Mayako ; Abola, Enrique ; Brooks, Charles L. ; Dixon, J. Scott ; Moult, John ; Stevens, Raymond C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2009-06, Vol.8 (6), p.455-463
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Tools for GPCR drug discovery
Author / Creator:Zhang, Ru ; Xie, Xin
Publisher:London: Nature Publishing Group UK
Journal title:Acta pharmacologica Sinica, 2012-03, Vol.33 (3), p.372-384
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Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex
Author / Creator:Nguyen, Anthony H. ; Thomsen, Alex R. B. ; Cahill, Thomas J. ; Huang, Rick ; Huang, Li-Yin ; Marcink, Tara ; Clarke, Oliver B. ; Heissel, Søren ; Masoudi, Ali ; Ben-Hail, Danya ; Samaan, Fadi ; Dandey, Venkata P. ; Tan, Yong Zi ; Hong, Chuan ; Mahoney, Jacob P. ; Triest, Sarah ; Little, John ; Chen, Xin ; Sunahara, Roger ; Steyaert, Jan ; Molina, Henrik ; Yu, Zhiheng ; des Georges, Amedee ; Lefkowitz, Robert J.
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2019-12, Vol.26 (12), p.1123-1131
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Commensal bacteria make GPCR ligands that mimic human signalling molecules
Author / Creator:Cohen, Louis J. ; Esterhazy, Daria ; Kim, Seong-Hwan ; Lemetre, Christophe ; Aguilar, Rhiannon R. ; Gordon, Emma A. ; Pickard, Amanda J. ; Cross, Justin R. ; Emiliano, Ana B. ; Han, Sun M. ; Chu, John ; Vila-Farres, Xavier ; Kaplitt, Jeremy ; Rogoz, Aneta ; Calle, Paula Y. ; Hunter, Craig ; Bitok, J. Kipchirchir ; Brady, Sean F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-09, Vol.549 (7670), p.48-53
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Compartmentalized GPCR Signaling from Intracellular Membranes
Author / Creator:Crilly, Stephanie E. ; Puthenveedu, Manojkumar A.
Publisher:New York: Springer US
Journal title:The Journal of membrane biology, 2021-06, Vol.254 (3), p.259-271
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GPCR-IPL score: multilevel featurization of GPCR–ligand interaction patterns and prediction of ligand functions from selectivity to biased activation
Author / Creator:Kumar, Surendra ; Teli, Mahesh K ; Kim, Mi-hyun
Publisher:England: Oxford University Press
Journal title:Briefings in bioinformatics, 2024-01, Vol.25 (2)
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Common activation mechanism of class A GPCRs
Author / Creator:Zhou, Qingtong ; Yang, Dehua ; Wu, Meng ; Guo, Yu ; Guo, Wanjing ; Zhong, Li ; Cai, Xiaoqing ; Dai, Antao ; Jang, Wonjo ; Shakhnovich, Eugene I ; Liu, Zhi-Jie ; Stevens, Raymond C ; Lambert, Nevin A ; Babu, M Madan ; Wang, Ming-Wei ; Zhao, Suwen
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2019-12, Vol.8
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Single-molecule FRET imaging of GPCR dimers in living cells
Author / Creator:Asher, Wesley B. ; Geggier, Peter ; Holsey, Michael D. ; Gilmore, Grant T. ; Pati, Avik K. ; Meszaros, Jozsef ; Terry, Daniel S. ; Mathiasen, Signe ; Kaliszewski, Megan J. ; McCauley, Mitchell D. ; Govindaraju, Alekhya ; Zhou, Zhou ; Harikumar, Kaleeckal G. ; Jaqaman, Khuloud ; Miller, Laurence J. ; Smith, Adam W. ; Blanchard, Scott C. ; Javitch, Jonathan A.
Publisher:New York: Nature Publishing Group US
Journal title:Nature methods, 2021-04, Vol.18 (4), p.397-405
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Conformational plasticity of the intracellular cavity of GPCR–G-protein complexes leads to G-protein promiscuity and selectivity
Author / Creator:Sandhu, Manbir ; Touma, Anja M. ; Dysthe, Matthew ; Sadler, Fredrik ; Sivaramakrishnan, Sivaraj ; Vaidehi, Nagarajan
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-06, Vol.116 (24), p.11956-11965
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Trends in GPCR drug discovery: new agents, targets and indications

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Selectivity determinants of GPCR–G-protein binding

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Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

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Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

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Structure and dynamics of GPCR signaling complexes

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Conformational biosensors reveal GPCR signalling from endosomes

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Targeting lipid GPCRs to treat type 2 diabetes mellitus — progress and challenges

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GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation

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β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation

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Molecular mechanism of GPCR-mediated arrestin activation

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GPCR activation mechanisms across classes and macro/microscales

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Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008

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Tools for GPCR drug discovery

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Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex

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Commensal bacteria make GPCR ligands that mimic human signalling molecules

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Compartmentalized GPCR Signaling from Intracellular Membranes

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GPCR-IPL score: multilevel featurization of GPCR–ligand interaction patterns and prediction of ligand functions from selectivity to biased activation

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Common activation mechanism of class A GPCRs

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Single-molecule FRET imaging of GPCR dimers in living cells

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Conformational plasticity of the intracellular cavity of GPCR–G-protein complexes leads to G-protein promiscuity and selectivity

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