The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in...
The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system
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Author / Creator
Correia, Susana S , Liu, Guang , Jacobson, Sarah , Bernier, Sylvie G , Tobin, Jenny V , Schwartzkopf, Chad D , Atwater, Emily , Lonie, Elisabeth , Rivers, Sam , Carvalho, Andrew , Germano, Peter , Tang, Kim , Iyengar, Rajesh R , Currie, Mark G , Hadcock, John R , Winrow, Christopher J and Jones, Juli E
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling plays an essential role in modulating neuroinflammation. CYR119 is a CNS-penetrant sGC stimulator that amplifies endogenous NO-sGC-cGMP signaling. We evaluated tar...
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Full title
The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_b9dc10997df94c7186de03737efe4dd1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b9dc10997df94c7186de03737efe4dd1
Other Identifiers
ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-021-02275-z
