Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
About this item
Full title
Author / Creator
Gröschel, Stefan , Hübschmann, Daniel , Raimondi, Francesco , Horak, Peter , Warsow, Gregor , Fröhlich, Martina , Klink, Barbara , Gieldon, Laura , Hutter, Barbara , Kleinheinz, Kortine , Bonekamp, David , Marschal, Oliver , Chudasama, Priya , Mika, Jagoda , Groth, Marie , Uhrig, Sebastian , Krämer, Stephen , Heining, Christoph , Heilig, Christoph E. , Richter, Daniela , Reisinger, Eva , Pfütze, Katrin , Eils, Roland , Wolf, Stephan , von Kalle, Christof , Brandts, Christian , Scholl, Claudia , Weichert, Wilko , Richter, Stephan , Bauer, Sebastian , Penzel, Roland , Schröck, Evelin , Stenzinger, Albrecht , Schlenk, Richard F. , Brors, Benedikt , Russell, Robert B. , Glimm, Hanno , Schlesner, Matthias and Fröhling, Stefan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Chordomas are rare bone tumors with few therapeutic options. Here we show, using whole-exome and genome sequencing within a precision oncology program, that advanced chordomas (
n
= 11) may be characterized by genomic patterns indicative of defective homologous recombination (HR) DNA repair and alterations affecting HR-related genes, includi...
Alternative Titles
Full title
Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
Authors, Artists and Contributors
Author / Creator
Hübschmann, Daniel
Raimondi, Francesco
Horak, Peter
Warsow, Gregor
Fröhlich, Martina
Klink, Barbara
Gieldon, Laura
Hutter, Barbara
Kleinheinz, Kortine
Bonekamp, David
Marschal, Oliver
Chudasama, Priya
Mika, Jagoda
Groth, Marie
Uhrig, Sebastian
Krämer, Stephen
Heining, Christoph
Heilig, Christoph E.
Richter, Daniela
Reisinger, Eva
Pfütze, Katrin
Eils, Roland
Wolf, Stephan
von Kalle, Christof
Brandts, Christian
Scholl, Claudia
Weichert, Wilko
Richter, Stephan
Bauer, Sebastian
Penzel, Roland
Schröck, Evelin
Stenzinger, Albrecht
Schlenk, Richard F.
Brors, Benedikt
Russell, Robert B.
Glimm, Hanno
Schlesner, Matthias
Fröhling, Stefan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ba10289481024dc5944d84dae65732a8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ba10289481024dc5944d84dae65732a8
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09633-9
