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ArticlesPeer ReviewedFull Text
Targeting FLT3 mutations in AML: review of current knowledge and evidence
Author / Creator:Daver, Naval ; Schlenk, Richard F. ; Russell, Nigel H. ; Levis, Mark J.
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2019-02, Vol.33 (2), p.299-312
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Genomic Classification and Prognosis in Acute Myeloid Leukemia
Author / Creator:Papaemmanuil, Elli ; Gerstung, Moritz ; Bullinger, Lars ; Gaidzik, Verena I ; Paschka, Peter ; Roberts, Nicola D ; Potter, Nicola E ; Heuser, Michael ; Thol, Felicitas ; Bolli, Niccolo ; Gundem, Gunes ; Van Loo, Peter ; Martincorena, Inigo ; Ganly, Peter ; Mudie, Laura ; McLaren, Stuart ; O’Meara, Sarah ; Raine, Keiran ; Jones, David R ; Teague, Jon W ; Butler, Adam P ; Greaves, Mel F ; Ganser, Arnold ; Döhner, Konstanze ; Schlenk, Richard F ; Döhner, Hartmut ; Campbell, Peter J
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2016-06, Vol.374 (23), p.2209-2221
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ArticlesPeer ReviewedFull Text
Precision oncology for acute myeloid leukemia using a knowledge bank approach
Author / Creator:Gerstung, Moritz ; Papaemmanuil, Elli ; Martincorena, Inigo ; Bullinger, Lars ; Gaidzik, Verena I ; Paschka, Peter ; Heuser, Michael ; Thol, Felicitas ; Bolli, Niccolo ; Ganly, Peter ; Ganser, Arnold ; McDermott, Ultan ; Döhner, Konstanze ; Schlenk, Richard F ; Döhner, Hartmut ; Campbell, Peter J
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2017-03, Vol.49 (3), p.332-340
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ArticlesPeer ReviewedFull Text
Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia
Author / Creator:Schlenk, Richard F ; Döhner, Konstanze ; Döhner, Hartmut ; Krauter, Jürgen ; Fröhling, Stefan ; Corbacioglu, Andrea ; Bullinger, Lars ; Habdank, Marianne ; Späth, Daniela ; Morgan, Michael ; Benner, Axel ; Schlegelberger, Brigitte ; Heil, Gerhard ; Ganser, Arnold
Publisher:Boston, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2008-05, Vol.358 (18), p.1909-1918
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ArticlesPeer ReviewedFull Text
Adding dasatinib to intensive treatment in core-binding factor acute myeloid leukemia—results of the AMLSG 11-08 trial
Author / Creator:Paschka, Peter ; Schlenk, Richard F ; Weber, Daniela ; Benner, Axel ; Bullinger, Lars ; Heuser, Michael ; Gaidzik, Verena I ; Thol, Felicitas ; Agrawal, Mridul ; Teleanu, Veronica ; Lübbert, Michael ; Fiedler, Walter ; Radsak, Markus ; Krauter, Jürgen ; Horst, Heinz-A. ; Greil, Richard ; Mayer, Karin ; Kündgen, Andrea ; Martens, Uwe ; Heil, Gerhard ; Salih, Helmut R ; Hertenstein, Bernd ; Schwänen, Carsten ; Wulf, Gerald ; Lange, Elisabeth ; Pfreundschuh, Michael ; Ringhoffer, Mark ; Girschikofsky, Michael ; Heinicke, Thomas ; Kraemer, Doris ; Göhring, Gudrun ; Ganser, Arnold ; Döhner, Konstanze ; Döhner, Hartmut
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2018-07, Vol.32 (7), p.1621-1630
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ArticlesPeer ReviewedFull Text
Use of Gene-Expression Profiling to Identify Prognostic Subclasses in Adult Acute Myeloid Leukemia
Author / Creator:Bullinger, Lars ; Döhner, Konstanze ; Döhner, Hartmut ; Bair, Eric ; Fröhling, Stefan ; Schlenk, Richard F ; Tibshirani, Robert ; Pollack, Jonathan R
Publisher:Boston, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2004-04, Vol.350 (16), p.1605-1616
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ArticlesPeer ReviewedFull Text
Requirement for LIM kinases in acute myeloid leukemia
Author / Creator:Jensen, Patrizia ; Carlet, Michela ; Schlenk, Richard F. ; Weber, Andrea ; Kress, Jana ; Brunner, Ines ; Słabicki, Mikołaj ; Grill, Gregor ; Weisemann, Simon ; Cheng, Ya-Yun ; Jeremias, Irmela ; Scholl, Claudia ; Fröhling, Stefan
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2020-12, Vol.34 (12), p.3173-3185
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ArticlesPeer ReviewedFull Text
Phase I study evaluating the Fc-optimized FLT3 antibody FLYSYN in AML patients with measurable residual disease
Author / Creator:Heitmann, Jonas S. ; Schlenk, Richard F. ; Dörfel, Daniela ; Kayser, Sabine ; Döhner, Konstanze ; Heuser, Michael ; Thol, Felicitas ; Kapp-Schwoerer, Silke ; Labrenz, Jannik ; Edelmann, Dominic ; Märklin, Melanie ; Vogel, Wichard ; Bethge, Wolfgang ; Walz, Juliane S. ; Große-Hovest, Ludger ; Steiner, Martin ; Jung, Gundram ; Salih, Helmut R.
Publisher:London: BioMed Central Ltd
Journal title:Journal of hematology and oncology, 2023-08, Vol.16 (1), p.1-96, Article 96
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ArticlesPeer ReviewedFull Text
Protocol of a prospective, multicentre phase I study to evaluate the safety, tolerability and preliminary efficacy of the bispecific PSMAxCD3 antibody CC-1 in patients with castration-resistant prosta...
Author / Creator:Heitmann, Jonas S ; Walz, Juliane S ; Pflügler, Martin ; Kauer, Joseph ; Schlenk, Richard F ; Jung, Gundram ; Salih, Helmut R
Publisher:England: British Medical Journal Publishing Group
Journal title:BMJ open, 2020-10, Vol.10 (10), p.e039639-e039639
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ArticlesPeer ReviewedFull Text
Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen
Author / Creator:Schmutz, Maximilian ; Zucknick, Manuela ; Schlenk, Richard F ; Mertens, Daniel ; Benner, Axel ; Weichenhan, Dieter ; Mücke, Oliver ; Döhner, Konstanze ; Plass, Christoph ; Bullinger, Lars ; Claus, Rainer
Publisher:London: BioMed Central Ltd
Journal title:Clinical epigenetics, 2023-10, Vol.15 (1), p.1-171, Article 171
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Q-HAM: a multicenter upfront randomized phase II trial of quizartinib and high-dose Ara-C plus mitoxantrone in relapsed/refractory AML with FLT3-ITD
Author / Creator:Jaramillo, Sonia ; Le Cornet, Lucian ; Kratzmann, Markus ; Krisam, Johannes ; Görner, Martin ; Hänel, Mathias ; Röllig, Christoph ; Wass, Maxi ; Scholl, Sebastian ; Ringhoffer, Mark ; Reichart, Alexander ; Steffen, Björn ; Kayser, Sabine ; Mikesch, Jan-Henrik ; Schaefer-Eckart, Kerstin ; Schubert, Jörg ; Geer, Thomas ; Martin, Sonja ; Kieser, Meinhard ; Sauer, Tim ; Kriegsmann, Katharina ; Hundemer, Michael ; Serve, Hubert ; Bornhäuser, Martin ; Müller-Tidow, Carsten ; Schlenk, Richard F
Publisher:London: BioMed Central Ltd
Journal title:Current controlled trials in cardiovascular medicine, 2023-09, Vol.24 (1), p.591-591, Article 591
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ArticlesPeer ReviewedFull Text
Management of patients with acute promyelocytic leukemia
Author / Creator:Kayser, Sabine ; Schlenk, Richard F. ; Platzbecker, Uwe
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2018-06, Vol.32 (6), p.1277-1294
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ArticlesPeer ReviewedFull Text
Identifying Prognostic SNPs in Clinical Cohorts: Complementing Univariate Analyses by Resampling and Multivariable Modeling
Author / Creator:Hieke, Stefanie ; Benner, Axel ; Schlenk, Richard F ; Schumacher, Martin ; Bullinger, Lars ; Binder, Harald
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-05, Vol.11 (5), p.e0155226-e0155226
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Rationale and design of the 2 by 2 factorial design GnG-trial: a randomized phase-III study to compare two schedules of gemtuzumab ozogamicin as adjunct to intensive induction therapy and to compare d...
Author / Creator:Jaramillo, Sonia ; Krisam, Johannes ; Le Cornet, Lucian ; Kratzmann, Markus ; Baumann, Lukas ; Sauer, Tim ; Crysandt, Martina ; Rank, Andreas ; Behringer, Dirk ; Teichmann, Lino ; Görner, Martin ; Trappe, Ralf-Ulrich ; Röllig, Christoph ; Krause, Stefan ; Hanoun, Maher ; Hopfer, Olaf ; Held, Gerhard ; Buske, Sebastian ; Fransecky, Lars ; Kayser, Sabine ; Schliemann, Christoph ; Schaefer-Eckart, Kerstin ; Al-Fareh, Yousef ; Schubert, Jörg ; Geer, Thomas ; Kaufmann, Martin ; Brecht, Arne ; Niemann, Dirk ; Kieser, Meinhard ; Bornhäuser, Martin ; Platzbecker, Uwe ; Serve, Hubert ; Baldus, Claudia D ; Müller-Tidow, Carsten ; Schlenk, Richard F
Publisher:England: BioMed Central
Journal title:Current controlled trials in cardiovascular medicine, 2021-11, Vol.22 (1), p.765-765, Article 765
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A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Dise...
Author / Creator:Janssen, Maike ; Schäkel, Ulrike ; Djuka Fokou, Carine ; Krisam, Johannes ; Stermann, Jacek ; Kriegsmann, Katharina ; Haberbosch, Isabella ; Novotny, Jan Philipp ; Weber, Stefan ; Vehreschild, Maria ; Bornhäuser, Martin ; Bullinger, Lars ; Schmitt, Michael ; Liebregts, Tobias ; Dreger, Peter ; Lorenz, Hanns-Martin ; Plaszczyca, Anna ; Bartenschlager, Ralf ; Müller, Barbara ; Kräusslich, Hans-Georg ; Halama, Niels ; Jäger, Dirk ; Schlenk, Richard F ; Leo, Albrecht ; Meuer, Stefan ; Weigand, Markus A ; Motsch, Johann ; Merle, Uta ; Denkinger, Claudia M ; Müller-Tidow, Carsten
Publisher:England: BioMed Central
Journal title:Current controlled trials in cardiovascular medicine, 2020-10, Vol.21 (1), p.828-828, Article 828
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NCT/DKFZ MASTER handbook of interpreting whole-genome, transcriptome, and methylome data for precision oncology
Author / Creator:Mock, Andreas ; Teleanu, Maria-Veronica ; Kreutzfeldt, Simon ; Heilig, Christoph E. ; Hüllein, Jennifer ; Möhrmann, Lino ; Jahn, Arne ; Hanf, Dorothea ; Kerle, Irina A. ; Singh, Hans Martin ; Hutter, Barbara ; Uhrig, Sebastian ; Fröhlich, Martina ; Neumann, Olaf ; Hartig, Andreas ; Brückmann, Sascha ; Hirsch, Steffen ; Grund, Kerstin ; Dikow, Nicola ; Lipka, Daniel B. ; Renner, Marcus ; Bhatti, Irfan Ahmed ; Apostolidis, Leonidas ; Schlenk, Richard F. ; Schaaf, Christian P. ; Stenzinger, Albrecht ; Schröck, Evelin ; Hübschmann, Daniel ; Heining, Christoph ; Horak, Peter ; Glimm, Hanno ; Fröhling, Stefan
Publisher:London: Nature Publishing Group UK
Journal title:NPJ precision oncology, 2023-10, Vol.7 (1), p.109-15, Article 109
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ArticlesPeer ReviewedFull Text
The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis
Author / Creator:Scholl, Claudia ; Bansal, Dimple ; Döhner, Konstanze ; Eiwen, Karina ; Huntly, Brian J P ; Lee, Benjamin H ; Rücker, Frank G ; Schlenk, Richard F ; Bullinger, Lars ; Döhner, Hartmut ; Gilliland, D Gary ; Fröhling, Stefan
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2007-04, Vol.117 (4), p.1037-1048
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Ruxolitinib is effective in the treatment of a patient with refractory T‐ALL
Author / Creator:Jaramillo, Sonia ; Hennemann, Hannah ; Horak, Peter ; Teleanu, Veronica ; Heilig, Christoph E. ; Hutter, Barbara ; Stenzinger, Albrecht ; Glimm, Hanno ; Goeppert, Benjamin ; Müller‐Tidow, Carsten ; Fröhling, Stefan ; Schönland, Stefan ; Schlenk, Richard F.
Publisher:United States: John Wiley & Sons, Inc
Journal title:EJHaem, 2021-02, Vol.2 (1), p.139-142
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ArticlesPeer ReviewedFull Text
Targeted Therapy Alone for Acute Promyelocytic Leukemia
Author / Creator:Lo-Coco, Francesco ; Di Donato, Laura ; Schlenk, Richard F
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2016-03, Vol.374 (12), p.1197-1198
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Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation
Author / Creator:Stone, Richard M ; Mandrekar, Sumithra J ; Sanford, Ben L ; Laumann, Kristina ; Geyer, Susan ; Bloomfield, Clara D ; Thiede, Christian ; Prior, Thomas W ; Döhner, Konstanze ; Marcucci, Guido ; Lo-Coco, Francesco ; Klisovic, Rebecca B ; Wei, Andrew ; Sierra, Jorge ; Sanz, Miguel A ; Brandwein, Joseph M ; de Witte, Theo ; Niederwieser, Dietger ; Appelbaum, Frederick R ; Medeiros, Bruno C ; Tallman, Martin S ; Krauter, Jürgen ; Schlenk, Richard F ; Ganser, Arnold ; Serve, Hubert ; Ehninger, Gerhard ; Amadori, Sergio ; Larson, Richard A ; Döhner, Hartmut
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2017-08, Vol.377 (5), p.454-464
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Targeting FLT3 mutations in AML: review of current knowledge and evidence

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Genomic Classification and Prognosis in Acute Myeloid Leukemia

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Precision oncology for acute myeloid leukemia using a knowledge bank approach

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Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia

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Adding dasatinib to intensive treatment in core-binding factor acute myeloid leukemia—results of the AMLSG 11-08 trial

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Use of Gene-Expression Profiling to Identify Prognostic Subclasses in Adult Acute Myeloid Leukemia

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Requirement for LIM kinases in acute myeloid leukemia

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Phase I study evaluating the Fc-optimized FLT3 antibody FLYSYN in AML patients with measurable residual disease

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Protocol of a prospective, multicentre phase I study to evaluate the safety, tolerability and preliminary efficacy of the bispecific PSMAxCD3 antibody CC-1 in patients with castration-resistant prosta...

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Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen

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Q-HAM: a multicenter upfront randomized phase II trial of quizartinib and high-dose Ara-C plus mitoxantrone in relapsed/refractory AML with FLT3-ITD

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Management of patients with acute promyelocytic leukemia

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Identifying Prognostic SNPs in Clinical Cohorts: Complementing Univariate Analyses by Resampling and Multivariable Modeling

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Rationale and design of the 2 by 2 factorial design GnG-trial: a randomized phase-III study to compare two schedules of gemtuzumab ozogamicin as adjunct to intensive induction therapy and to compare d...

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A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Dise...

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NCT/DKFZ MASTER handbook of interpreting whole-genome, transcriptome, and methylome data for precision oncology

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The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis

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Ruxolitinib is effective in the treatment of a patient with refractory T‐ALL

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Targeted Therapy Alone for Acute Promyelocytic Leukemia

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Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

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