PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Re...
PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The p53 transcription factor is a master regulator of cellular stress responses inhibited by repressors such as MDM2 and the phosphatase PPM1D. Activation of p53 with pharmacological inhibitors of its repressors is being tested in clinical trials for cancer therapy, but efficacy has been limited by poor induction of tumor cell death. We demonstrate...
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PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response
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TN_cdi_doaj_primary_oai_doaj_org_article_ba96d94410b24d0bac5244271212e7b7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ba96d94410b24d0bac5244271212e7b7
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-35089-5
