Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation
Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Activation of autophagy and elevation of glutamine synthesis represent key adaptations to maintain amino acid balance during starvation. In this study, we investigate the role of autophagy and glutamine on the regulation of mTORC1, a critical kinase that regulates cell growth and proliferation. We report that supplementation of glutamine alone is s...
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Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation
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TN_cdi_doaj_primary_oai_doaj_org_article_baa64e48583c47e993cde6f66f813394
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_baa64e48583c47e993cde6f66f813394
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00369-y