Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
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Author / Creator
Rines, Amy K. , Chang, Hsiang-Chun , Wu, Rongxue , Sato, Tatsuya , Khechaduri, Arineh , Kouzu, Hidemichi , Shapiro, Jason , Shang, Meng , Burke, Michael A. , Abdelwahid, Eltyeb , Jiang, Xinghang , Chen, Chunlei , Rawlings, Tenley A. , Lopaschuk, Gary D. , Schumacker, Paul T. , Abel, E. Dale and Ardehali, Hossein
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Ischaemic heart disease limits oxygen and metabolic substrate availability to the heart, resulting in tissue death. Here, we demonstrate that the AMP-activated protein kinase (AMPK)-related protein Snf1-related kinase (SNRK) decreases cardiac metabolic substrate usage and mitochondrial uncoupling, and protects against ischaemia/reperfusion. Hearts...
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Full title
Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
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TN_cdi_doaj_primary_oai_doaj_org_article_bae6e26f24c34045be0fbe2c38eff574
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bae6e26f24c34045be0fbe2c38eff574
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14095
