Age‐ and disease‐specific reference values for neurofilament light presented in an online interactiv...
Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface
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Author / Creator
Vermunt, Lisa , Otte, Marco , Verberk, Inge M. W. , Killestein, Joep , Lemstra, Afina W. , Flier, Wiesje M. , Pijnenburg, Yolande A. L. , Vijverberg, Everard G. B. , Bouwman, Femke H. , Gravesteijn, Gido , Berg, Wilma D. J. , Scheltens, Philip , Harten, Argonde C. , Willemse, Eline A. J. and Teunissen, Charlotte E.
Publisher
United States: John Wiley & Sons, Inc
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Language
English
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Publisher
United States: John Wiley & Sons, Inc
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Contents
Interpretation of axonal damage biomarker Neurofilament Light chain (NfL) concentrations is difficult due to the lack of age‐specific and disease‐specific reference values. We here developed an interactive interface to support interpretation of NfL results in human body fluids. We used NfL values of 1698 individuals without a neurological disorder, aged 19–85 years, and patients with MS and dementias. Percentile regression estimates per diagnosis populate interactive graphs, alongside NfL background information (available on: https://mybiomarkers.shinyapps.io/Neurofilament). This accessible interface provides reference for interpretation of the individual patient results for clinicians. It showcases an adaptable method to support interpretation of age‐dependent biomarkers in neurology....
Alternative Titles
Full title
Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface
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TN_cdi_doaj_primary_oai_doaj_org_article_bb2c5e3e1a0f400bab820db7e4aec1eb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bb2c5e3e1a0f400bab820db7e4aec1eb
Other Identifiers
ISSN
2328-9503
E-ISSN
2328-9503
DOI
10.1002/acn3.51676
