Acetylation of C/EBPα inhibits its granulopoietic function
Acetylation of C/EBPα inhibits its granulopoietic function
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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CCAAT/enhancer-binding protein alpha (C/EBPα) is an essential transcription factor for myeloid lineage commitment. Here we demonstrate that acetylation of C/EBPα at lysine residues K298 and K302, mediated at least in part by general control non-derepressible 5 (GCN5), impairs C/EBPα DNA-binding ability and modulates C/EBPα transcriptional activity....
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Acetylation of C/EBPα inhibits its granulopoietic function
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TN_cdi_doaj_primary_oai_doaj_org_article_bbfd33738c434d31b7e3a3a8aebe9853
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bbfd33738c434d31b7e3a3a8aebe9853
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10968
