RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone...
RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis
About this item
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Author / Creator
Yue, Zhiying , Niu, Xin , Yuan, Zengjin , Qin, Qin , Jiang, Wenhao , He, Liang , Gao, Jingduo , Ding, Yi , Liu, Yanxi , Xu, Ziwei , Li, Zhenxi , Yang, Zhengfeng , Li, Rong , Xue, Xiwen , Gao, Yankun , Yue, Fei , Zhang, Xiang H-F , Hu, Guohong , Wang, Yi , Li, Yi , Chen, Geng , Siwko, Stefan , Gartland, Alison , Wang, Ning , Xiao, Jianru , Liu, Mingyao and Luo, Jian
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
United States: American Society for Clinical Investigation
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More information
Scope and Contents
Contents
Therapeutics targeting osteoclasts are commonly used treatments for bone metastasis; however, whether and how osteoclasts regulate premetastatic niche and bone tropism are largely unknown. In this study, we report that osteoclast precursors (OPs) can function as a premetastatic niche component that facilitates breast cancer (BCa) bone metastasis at...
Alternative Titles
Full title
RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis
Authors, Artists and Contributors
Author / Creator
Niu, Xin
Yuan, Zengjin
Qin, Qin
Jiang, Wenhao
He, Liang
Gao, Jingduo
Ding, Yi
Liu, Yanxi
Xu, Ziwei
Li, Zhenxi
Yang, Zhengfeng
Li, Rong
Xue, Xiwen
Gao, Yankun
Yue, Fei
Zhang, Xiang H-F
Hu, Guohong
Wang, Yi
Li, Yi
Chen, Geng
Siwko, Stefan
Gartland, Alison
Wang, Ning
Xiao, Jianru
Liu, Mingyao
Luo, Jian
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_bc28f8256df64fe189ac58cf485bf56c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bc28f8256df64fe189ac58cf485bf56c
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI144579
