Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer
Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Oncogenic KRAS mutations are prevalent in human cancers, but effective treatment of KRAS-mutant malignancies remains a major challenge in the clinic. Increasing evidence suggests that aberrant metabolism plays a central role in KRAS-driven oncogenic transformation. The aim of this study is to identify selective metabolic dependency induced by mutan...
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Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_bc76e919384f491d926df24e6badec93
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bc76e919384f491d926df24e6badec93
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ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-022-02240-5
