Phosphatase PP2A enhances MCL-1 protein half-life in multiple myeloma cells
Phosphatase PP2A enhances MCL-1 protein half-life in multiple myeloma cells
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Multiple myeloma (MM), a treatable but incurable malignancy, is characterized by the growth of clonal plasma cells in protective niches in the bone marrow. MM cells depend on expression of BCL-2 family proteins, in particular MCL-1, for survival. The regulation of MCL-1 is complex and cell type-dependent. Unraveling the exact mechanism by which MCL...
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Phosphatase PP2A enhances MCL-1 protein half-life in multiple myeloma cells
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TN_cdi_doaj_primary_oai_doaj_org_article_bcb49f1ebfea49e3a91bb70a53cb4205
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bcb49f1ebfea49e3a91bb70a53cb4205
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-020-03351-7
