Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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The response to hypoxia in animals involves the expression of multiple genes regulated by the αβ-hypoxia-inducible transcription factors (HIFs). The hypoxia-sensing mechanism involves oxygen limited hydroxylation of prolyl residues in the N- and C-terminal oxygen-dependent degradation domains (NODD and CODD) of HIFα isoforms, as catalysed by prolyl...
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Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
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TN_cdi_doaj_primary_oai_doaj_org_article_bcbb0397431d45b6a10192b43d152868
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bcbb0397431d45b6a10192b43d152868
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12673
