Regulatory mechanisms of incomplete huntingtin mRNA splicing
Regulatory mechanisms of incomplete huntingtin mRNA splicing
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Huntington’s disease is caused by a CAG repeat expansion in exon 1 of the
HTT
gene. We have previously shown that exon 1
HTT
does not always splice to exon 2 producing a small transcript (
HTTexon1
) that encodes the highly pathogenic exon 1 HTT protein. The mechanisms by which this incomplete splicing occurs are unknown. Here, we...
Alternative Titles
Full title
Regulatory mechanisms of incomplete huntingtin mRNA splicing
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TN_cdi_doaj_primary_oai_doaj_org_article_bd15556f976d414a8586ab29954b52a8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bd15556f976d414a8586ab29954b52a8
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-06281-3
