TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity
TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity
About this item
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Author / Creator
Riquelme, Paloma , Haarer, Jan , Kammler, Anja , Walter, Lisa , Tomiuk, Stefan , Ahrens, Norbert , Wege, Anja K. , Goecze, Ivan , Zecher, Daniel , Banas, Bernhard , Spang, Rainer , Fändrich, Fred , Lutz, Manfred B. , Sawitzki, Birgit , Schlitt, Hans J. , Ochando, Jordi , Geissler, Edward K. and Hutchinson, James A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based adjunct immunosuppressive therapy in solid organ transplantation. It is hypothesised that recipient CD4
+
T cell responses are actively regulated through direct allorecognition of donor-derived Mregs. Here we show that human Mregs convert allogeneic CD4
+...
Alternative Titles
Full title
TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_bde1072b3b4842efb0f1df25fc4a3f9e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bde1072b3b4842efb0f1df25fc4a3f9e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05167-8
