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Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repr...

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repr...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bea5fbe30e2340e383f4864410b7a2fd

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

About this item

Full title

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2021-06, Vol.12 (1), p.3933-19, Article 3933

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Thymic T cell development and T cell receptor repertoire selection are dependent on essential molecular cues provided by thymic epithelial cells (TEC). TEC development and function are regulated by their epigenetic landscape, in which the repressive H3K27me3 epigenetic marks are catalyzed by polycomb repressive complex 2 (PRC2). Here we show that a...

Alternative Titles

Full title

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_bea5fbe30e2340e383f4864410b7a2fd

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bea5fbe30e2340e383f4864410b7a2fd

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-021-24158-w

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