Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis
Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The beta‑site amyloid precursor protein (APP) cleaving enzyme (BACE1) was discovered due to its “amyloidogenic” activity which contributes to the production of amyloid-beta (Aβ) peptides. However, BACE1 also possesses an “amyloidolytic” activity, whereby it degrades longer Aβ peptides into a non‑toxic Aβ34 intermediate. Here, we examine conditions...
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Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis
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TN_cdi_doaj_primary_oai_doaj_org_article_bf1fc4064fa54fe8be2da48d70db411d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bf1fc4064fa54fe8be2da48d70db411d
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-28846-z
