CD98hc is a target for brain delivery of biotherapeutics
CD98hc is a target for brain delivery of biotherapeutics
About this item
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Author / Creator
Chew, Kylie S. , Wells, Robert C. , Moshkforoush, Arash , Chan, Darren , Lechtenberg, Kendra J. , Tran, Hai L. , Chow, Johann , Kim, Do Jin , Robles-Colmenares, Yaneth , Srivastava, Devendra B. , Tong, Raymond K. , Tong, Mabel , Xa, Kaitlin , Yang, Alexander , Zhou, Yinhan , Akkapeddi, Padma , Annamalai, Lakshman , Bajc, Kaja , Blanchette, Marie , Cherf, Gerald Maxwell , Earr, Timothy K. , Gill, Audrey , Huynh, David , Joy, David , Knight, Kristen N. , Lac, Diana , Leung, Amy Wing-Sze , Lexa, Katrina W. , Liau, Nicholas P. D. , Becerra, Isabel , Malfavon, Mario , McInnes, Joseph , Nguyen, Hoang N. , Lozano, Edwin I. , Pizzo, Michelle E. , Roche, Elysia , Sacayon, Patricia , Calvert, Meredith E. K. , Daneman, Richard , Dennis, Mark S. , Duque, Joseph , Gadkar, Kapil , Lewcock, Joseph W. , Mahon, Cathal S. , Meisner, René , Solanoy, Hilda , Thorne, Robert G. , Watts, Ryan J. , Zuchero, Y. Joy Yu and Kariolis, Mihalis S.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport vehicle targeting the CD98 heavy chain (CD98hc or SLC3A2) of heterodimeric amino acid transporters (TV
CD98hc
). The pharmacokinetic and biodistribution prop...
Alternative Titles
Full title
CD98hc is a target for brain delivery of biotherapeutics
Authors, Artists and Contributors
Author / Creator
Wells, Robert C.
Moshkforoush, Arash
Chan, Darren
Lechtenberg, Kendra J.
Tran, Hai L.
Chow, Johann
Kim, Do Jin
Robles-Colmenares, Yaneth
Srivastava, Devendra B.
Tong, Raymond K.
Tong, Mabel
Xa, Kaitlin
Yang, Alexander
Zhou, Yinhan
Akkapeddi, Padma
Annamalai, Lakshman
Bajc, Kaja
Blanchette, Marie
Cherf, Gerald Maxwell
Earr, Timothy K.
Gill, Audrey
Huynh, David
Joy, David
Knight, Kristen N.
Lac, Diana
Leung, Amy Wing-Sze
Lexa, Katrina W.
Liau, Nicholas P. D.
Becerra, Isabel
Malfavon, Mario
McInnes, Joseph
Nguyen, Hoang N.
Lozano, Edwin I.
Pizzo, Michelle E.
Roche, Elysia
Sacayon, Patricia
Calvert, Meredith E. K.
Daneman, Richard
Dennis, Mark S.
Duque, Joseph
Gadkar, Kapil
Lewcock, Joseph W.
Mahon, Cathal S.
Meisner, René
Solanoy, Hilda
Thorne, Robert G.
Watts, Ryan J.
Zuchero, Y. Joy Yu
Kariolis, Mihalis S.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c0dcaba8ffc04890ade94c8b75b21509
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c0dcaba8ffc04890ade94c8b75b21509
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-40681-4
