Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signature...
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
About this item
Full title
Author / Creator
Robinson, Philip S. , Thomas, Laura E. , Abascal, Federico , Jung, Hyunchul , Harvey, Luke M. R. , West, Hannah D. , Olafsson, Sigurgeir , Lee, Bernard C. H. , Coorens, Tim H. H. , Lee-Six, Henry , Butlin, Laura , Lander, Nicola , Truscott, Rebekah , Sanders, Mathijs A. , Lensing, Stefanie V. , Buczacki, Simon J. A. , ten Hoopen, Rogier , Coleman, Nicholas , Brunton-Sim, Roxanne , Rushbrook, Simon , Saeb-Parsy, Kourosh , Lalloo, Fiona , Campbell, Peter J. , Martincorena, Iñigo , Sampson, Julian R. and Stratton, Michael R.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Cellular DNA damage caused by reactive oxygen species is repaired by the base excision repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic
MUTYH
mutations cause predisposition to colorectal adenomas and carcinoma. However, the mechanistic progression from germline
MUTYH
mutations to MUTYH-Associated Polypo...
Alternative Titles
Full title
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
Authors, Artists and Contributors
Author / Creator
Thomas, Laura E.
Abascal, Federico
Jung, Hyunchul
Harvey, Luke M. R.
West, Hannah D.
Olafsson, Sigurgeir
Lee, Bernard C. H.
Coorens, Tim H. H.
Lee-Six, Henry
Butlin, Laura
Lander, Nicola
Truscott, Rebekah
Sanders, Mathijs A.
Lensing, Stefanie V.
Buczacki, Simon J. A.
ten Hoopen, Rogier
Coleman, Nicholas
Brunton-Sim, Roxanne
Rushbrook, Simon
Saeb-Parsy, Kourosh
Lalloo, Fiona
Campbell, Peter J.
Martincorena, Iñigo
Sampson, Julian R.
Stratton, Michael R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c14b563faf084d9f9abf9b953d1b62bf
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c14b563faf084d9f9abf9b953d1b62bf
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-31341-0
