Proteolysis-targeting chimeras (PROTACs) in cancer therapy
Proteolysis-targeting chimeras (PROTACs) in cancer therapy
About this item
Full title
Author / Creator
Li, Xinyi , Pu, Wenchen , Zheng, Qingquan , Ai, Min , Chen, Song and Peng, Yong
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Proteolysis-targeting chimeras (PROTACs) are engineered techniques for targeted protein degradation. A bifunctional PROTAC molecule with two covalently-linked ligands recruits target protein and E3 ubiquitin ligase together to trigger proteasomal degradation of target protein by the ubiquitin-proteasome system. PROTAC has emerged as a promising app...
Alternative Titles
Full title
Proteolysis-targeting chimeras (PROTACs) in cancer therapy
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c273e691a7f44a8f8991866c6367ccfd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c273e691a7f44a8f8991866c6367ccfd
Other Identifiers
ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/s12943-021-01434-3
