G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxid...
G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin
About this item
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Author / Creator
Wang, Ya-fang , Zhang, Jie , Su, Yi , Shen, Yan-yan , Jiang, Dong-xian , Hou, Ying-yong , Geng, Mei-yu , Ding, Jian and Chen, Yi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
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Scope and Contents
Contents
G9a, a H3K9 methyltransferase, shows elevated expression in many types of human cancers, particularly breast cancer. However, the tumorigenic mechanism of G9a is still far from clear. Here we report that G9a exerts its oncogenic function in breast cancer by repressing hephaestin and destruction cellular iron homeostasis. In the case of pharmacologi...
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Full title
G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c2b4a30f130740a69c6fdad77d98f0fb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c2b4a30f130740a69c6fdad77d98f0fb
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00350-9
