The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocyte...
The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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DNA double-strand breaks (DSBs) are toxic to mammalian cells. However, during meiosis, more than 200 DSBs are generated deliberately, to ensure reciprocal recombination and orderly segregation of homologous chromosomes. If left unrepaired, meiotic DSBs can cause aneuploidy in gametes and compromise viability in offspring. Oocytes in which DSBs pers...
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The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes
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TN_cdi_doaj_primary_oai_doaj_org_article_c2bf829fec2b403580972f4e566da03c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c2bf829fec2b403580972f4e566da03c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16441-z
