Human thymopoiesis produces polyspecific CD8+ α/β T cells responding to multiple viral antigens
Human thymopoiesis produces polyspecific CD8+ α/β T cells responding to multiple viral antigens
About this item
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Author / Creator
Quiniou, Valentin , Barennes, Pierre , Mhanna, Vanessa , Stys, Paul , Vantomme, Helene , Zhou, Zhicheng , Martina, Federica , Coatnoan, Nicolas , Barbie, Michele , Pham, Hang-Phuong , Clémenceau, Béatrice , Vie, Henri , Shugay, Mikhail , Six, Adrien , Brandao, Barbara , Mallone, Roberto , Mariotti-Ferrandiz, Encarnita and Klatzmann, David
Publisher
England: eLife Sciences Publication
Journal title
Language
English
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Publication information
Publisher
England: eLife Sciences Publication
Subjects
More information
Scope and Contents
Contents
T-cell receptors (TCRs) are formed by stochastic gene rearrangements, theoretically generating >10
19
sequences. They are selected during thymopoiesis, which releases a repertoire of about 10
8
unique TCRs per individual. How evolution shaped a process that produces TCRs that can effectively handle a countless and evolving set of infect...
Alternative Titles
Full title
Human thymopoiesis produces polyspecific CD8+ α/β T cells responding to multiple viral antigens
Authors, Artists and Contributors
Author / Creator
Barennes, Pierre
Mhanna, Vanessa
Stys, Paul
Vantomme, Helene
Zhou, Zhicheng
Martina, Federica
Coatnoan, Nicolas
Barbie, Michele
Pham, Hang-Phuong
Clémenceau, Béatrice
Vie, Henri
Shugay, Mikhail
Six, Adrien
Brandao, Barbara
Mallone, Roberto
Mariotti-Ferrandiz, Encarnita
Klatzmann, David
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c330db7a9f61475c8f6b69524299a6bc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c330db7a9f61475c8f6b69524299a6bc
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.81274
