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ArticlesPeer ReviewedFull Text
An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity
Author / Creator:Debruycker, Vincent ; Hutchin, Andrew ; Masureel, Matthieu ; Ficici, Emel ; Martens, Chloé ; Legrand, Pierre ; Stein, Richard A. ; Mchaourab, Hassane S. ; Faraldo-Gómez, José D. ; Remaut, Han ; Govaerts, Cédric
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2020-09, Vol.27 (9), p.829-835
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ArticlesPeer ReviewedFull Text
Predicting the polyspecificity of aminoacyl-tRNA synthetase for non-canonical amino acids using molecular dynamics simulation and MM/PBSA
Author / Creator:Lee, Dongheon ; Choi, Jong-il
Publisher:United States: Public Library of Science
Journal title:PloS one, 2025-01, Vol.20 (1), p.e0316907
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ArticlesPeer ReviewedFull Text
Induced Polyspecificity of Human Secretory Immunoglobulin A Antibodies: Is It Possible to Improve Their Ability to Bind Pathogens?
Author / Creator:Gorshkova, Ekaterina N. ; Pashova, Shina ; Vasilenko, Ekaterina A. ; Tchurina, Tatiana S. ; Razzorenova, Elizaveta A. ; Starkina, Olga V. ; Dimitrova, Petya ; Pashov, Anastas ; Vassilev, Tchavdar Lubenov
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Pharmacology, 2022-07, Vol.107 (7-8), p.341-350
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ArticlesPeer ReviewedFull Text
Intravenous Immunoglobulin with Enhanced Polyspecificity Improves Survival in Experimental Sepsis and Aseptic Systemic Inflammatory Response Syndromes
Author / Creator:Djoumerska-Alexieva, Iglika ; Roumenina, Lubka ; Pashov, Anastas ; Dimitrov, Jordan ; Hadzhieva, Maya ; Lindig, Sandro ; Voynova, Elisaveta ; Dimitrova, Petya ; Ivanovska, Nina ; Bockmeyer, Clemens ; Stefanova, Zvetanka ; Fitting, Catherine ; Bläss, Markus ; Claus, Ralf ; von Gunten, Stephan ; Kaveri, Srini ; Cavaillon, Jean-Marc ; Bauer, Michael ; Vassilev, Tchavdar
Publisher:England: BioMed Central
Journal title:Molecular medicine (Cambridge, Mass.), 2015-01, Vol.21 (1), p.1002-1010
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A simple mathematical approach to the analysis of polypharmacology and polyspecificity data
Author / Creator:Maggiora, Gerry ; Gokhale, Vijay
Publisher:England: Faculty of 1000 Ltd
Journal title:F1000 research, 2017, Vol.6, p.788
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Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10
Author / Creator:Finton, Kathryn A. K. ; Larimore, Kevin ; Larman, H. Benjamin ; Friend, Della ; Correnti, Colin ; Rupert, Peter B. ; Elledge, Stephen J. ; Greenberg, Philip D. ; Strong, Roland K.
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2013-09, Vol.9 (9), p.e1003639-e1003639
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ArticlesPeer ReviewedFull Text
Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10: e1003639
Author / Creator:Finton, Kathryn AK ; Larimore, Kevin ; Larman, H Benjamin ; Friend, Della ; Correnti, Colin ; Rupert, Peter B ; Elledge, Stephen J ; Greenberg, Philip D ; Strong, Roland K
Publisher:San Francisco: Public Library of Science
Journal title:PLoS pathogens, 2013-09, Vol.9 (9)
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ArticlesPeer ReviewedFull Text
Quinoxaline-substituted chalcones as new inhibitors of breast cancer resistance protein ABCG2: polyspecificity at B-ring position
Author / Creator:Di Pietro, Attilio ; Chiaradia-Delatorre, Louise D. ; Gauthier, Charlotte ; Mascarello, Alessandra ; Yunes, Rosendo A. ; Nunes, Ricardo J. ; Crecynski-Pasa, Tania B. ; Leal, Paulo C. ; Winter, Evelyn ; Gozzi, Gustavo ; Daflon-Yunes, Nathalia ; Terreux, Raphael ; Cadena, Silvia
Publisher:New Zealand: Dove Medical Press Limited
Journal title:Drug design, development and therapy, 2014-01, Vol.8 (default), p.609-619
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ArticlesPeer ReviewedFull Text
New structure-activity relationships of chalcone inhibitors of breast cancer resistance protein: polyspecificity toward inhibition and critical substitutions against cytotoxicity
Author / Creator:Di Pietro, Attilio ; Pereira Rangel ; Winter, Eve ; Gauthier ; Terreux, Raphael ; Chiaradia-Delatorre ; Mascarello ; Nunes ; Yunes ; Creczynski Pasa ; Macalou ; Lorendeau, Doriane ; Baubichon Cortay ; Ferreira-Pereira
Publisher:New Zealand: Dove Medical Press Limited
Journal title:Drug design, development and therapy, 2013-01, Vol.7 (default), p.1043-1052
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ArticlesPeer ReviewedFull Text
An in depth analysis of the concept of “polyspecificity” assumed to characterize TCR/BCR recognition
Author / Creator:Cohn, Melvin
Publisher:New York: Humana Press Inc
Journal title:Immunologic research, 2008-02, Vol.40 (2), p.128-147
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ArticlesPeer ReviewedFull Text
Polyspecificity of antimicrosomal thyroid antibodies in hepatitis C virus–related infection
Author / Creator:Peoc’h, Katell ; Dubel, Laurence ; Chazouillères, Olivier ; Ocwieja, Thierry ; Duron, Françoise ; Poupon, Raoul ; Johanet, Catherine
Publisher:Oxford: Elsevier Inc
Journal title:The American journal of gastroenterology, 2001-10, Vol.96 (10), p.2978-2983
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ArticlesPeer ReviewedFull Text
Human thymopoiesis produces polyspecific CD8+ α/β T cells responding to multiple viral antigens
Author / Creator:Quiniou, Valentin ; Barennes, Pierre ; Mhanna, Vanessa ; Stys, Paul ; Vantomme, Helene ; Zhou, Zhicheng ; Martina, Federica ; Coatnoan, Nicolas ; Barbie, Michele ; Pham, Hang-Phuong ; Clémenceau, Béatrice ; Vie, Henri ; Shugay, Mikhail ; Six, Adrien ; Brandao, Barbara ; Mallone, Roberto ; Mariotti-Ferrandiz, Encarnita ; Klatzmann, David
Publisher:England: eLife Sciences Publication
Journal title:eLife, 2023-03, Vol.12
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ArticlesFull Text
Combinatorial Exploration of Multidrug Polyspecificity in Efflux Pumps
Author / Creator:Cunden, Fabio Deelan ; Jimenez-Castellanos, Juan Carlos
Publisher:Ithaca: Cornell University Library, arXiv.org
Journal title:arXiv.org, 2024-10
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ArticlesFull Text
Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein
Author / Creator:Le, Christina A. ; Harvey, Daniel S. ; Aller, Stephen G.
Publisher:Chester: International Union of Crystallography
Journal title:IUCrJ, 2020-07, Vol.7 (4), p.663-672
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ArticlesPeer ReviewedFull Text
Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory
Author / Creator:Van Regenmortel, Marc
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2016-09, Vol.17 (9), p.1591-1591
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ArticlesPeer ReviewedFull Text
Directed Mutational Strategies Reveal Drug Binding and Transport by the MDR Transporters of Candida albicans
Author / Creator:Banerjee, Atanu ; Pata, Jorgaq ; Sharma, Suman ; Monk, Brian C. ; Falson, Pierre ; Prasad, Rajendra
Publisher:Switzerland: MDPI
Journal title:Journal of fungi (Basel), 2021-01, Vol.7 (2), p.68
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Newsletter articlesFull Text
Energetic and structural control of polyspecificity in a multidrug transporter
Publisher:NewsRX LLC
Journal title:News of Science, 2025, p.822
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ArticlesPeer ReviewedFull Text
Polyspecificity of Monoclonal Lupus Autoantibodies Produced by Human-Human Hybridomas
Author / Creator:Shoenfeld, Yehuda ; Rauch, Joyce ; Massicotte, Hélene ; Datta, Syamal K ; André-Schwartz, Janine ; Stollar, B. David ; Schwartz, Robert S
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 1983-02, Vol.308 (8), p.414-420
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Toward Drug-Like Multispecific Antibodies by Design
Author / Creator:Sawant, Manali S. ; Streu, Craig N. ; Wu, Lina ; Tessier, Peter M.
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2020-10, Vol.21 (20), p.7496
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Protein language models enable prediction of polyreactivity of monospecific, bispecific, and heavy-chain-only antibodies
Author / Creator:Yu, Xin ; Vangjeli, Kostika ; Prakash, Anusha ; Chhaya, Meha ; Stanley, Samantha J ; Cohen, Noah ; Huang, Lili
Publisher:United States: Oxford University Press
Journal title:Antibody therapeutics, 2024-07, Vol.7 (3), p.199-208
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Showing 1 to 20 of 131 results

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An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity

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Predicting the polyspecificity of aminoacyl-tRNA synthetase for non-canonical amino acids using molecular dynamics simulation and MM/PBSA

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Induced Polyspecificity of Human Secretory Immunoglobulin A Antibodies: Is It Possible to Improve Their Ability to Bind Pathogens?

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Intravenous Immunoglobulin with Enhanced Polyspecificity Improves Survival in Experimental Sepsis and Aseptic Systemic Inflammatory Response Syndromes

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A simple mathematical approach to the analysis of polypharmacology and polyspecificity data

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Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10

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Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10: e1003639

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Quinoxaline-substituted chalcones as new inhibitors of breast cancer resistance protein ABCG2: polyspecificity at B-ring position

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New structure-activity relationships of chalcone inhibitors of breast cancer resistance protein: polyspecificity toward inhibition and critical substitutions against cytotoxicity

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An in depth analysis of the concept of “polyspecificity” assumed to characterize TCR/BCR recognition

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Polyspecificity of antimicrosomal thyroid antibodies in hepatitis C virus–related infection

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Human thymopoiesis produces polyspecific CD8+ α/β T cells responding to multiple viral antigens

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Combinatorial Exploration of Multidrug Polyspecificity in Efflux Pumps

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Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein

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Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory

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Directed Mutational Strategies Reveal Drug Binding and Transport by the MDR Transporters of Candida albicans

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Energetic and structural control of polyspecificity in a multidrug transporter

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Polyspecificity of Monoclonal Lupus Autoantibodies Produced by Human-Human Hybridomas

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Toward Drug-Like Multispecific Antibodies by Design

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Protein language models enable prediction of polyreactivity of monospecific, bispecific, and heavy-chain-only antibodies

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