High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+...
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer
About this item
Full title
Author / Creator
Palafox, Marta , Monserrat, Laia , Bellet, Meritxell , Villacampa, Guillermo , Gonzalez-Perez, Abel , Oliveira, Mafalda , Brasó-Maristany, Fara , Ibrahimi, Nusaibah , Kannan, Srinivasaraghavan , Mina, Leonardo , Herrera-Abreu, Maria Teresa , Òdena, Andreu , Sánchez-Guixé, Mònica , Capelán, Marta , Azaro, Analía , Bruna, Alejandra , Rodríguez, Olga , Guzmán, Marta , Grueso, Judit , Viaplana, Cristina , Hernández, Javier , Su, Faye , Lin, Kui , Clarke, Robert B. , Caldas, Carlos , Arribas, Joaquín , Michiels, Stefan , García-Sanz, Alicia , Turner, Nicholas C. , Prat, Aleix , Nuciforo, Paolo , Dienstmann, Rodrigo , Verma, Chandra S. , Lopez-Bigas, Nuria , Scaltriti, Maurizio , Arnedos, Monica , Saura, Cristina and Serra, Violeta
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
CDK4/6 inhibitors combined with endocrine therapy have demonstrated higher antitumor activity than endocrine therapy alone for the treatment of advanced estrogen receptor-positive breast cancer. Some of these tumors are de novo resistant to CDK4/6 inhibitors and others develop acquired resistance. Here, we show that p16 overexpression is associated...
Alternative Titles
Full title
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer
Authors, Artists and Contributors
Author / Creator
Monserrat, Laia
Bellet, Meritxell
Villacampa, Guillermo
Gonzalez-Perez, Abel
Oliveira, Mafalda
Brasó-Maristany, Fara
Ibrahimi, Nusaibah
Kannan, Srinivasaraghavan
Mina, Leonardo
Herrera-Abreu, Maria Teresa
Òdena, Andreu
Sánchez-Guixé, Mònica
Capelán, Marta
Azaro, Analía
Bruna, Alejandra
Rodríguez, Olga
Guzmán, Marta
Grueso, Judit
Viaplana, Cristina
Hernández, Javier
Su, Faye
Lin, Kui
Clarke, Robert B.
Caldas, Carlos
Arribas, Joaquín
Michiels, Stefan
García-Sanz, Alicia
Turner, Nicholas C.
Prat, Aleix
Nuciforo, Paolo
Dienstmann, Rodrigo
Verma, Chandra S.
Lopez-Bigas, Nuria
Scaltriti, Maurizio
Arnedos, Monica
Saura, Cristina
Serra, Violeta
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c3a330e420d34dc992aab0ec2b80986a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c3a330e420d34dc992aab0ec2b80986a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32828-6
