Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal an...
Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The transcriptional effector SMAD4 is a core component of the TGF-β family signaling pathways. However, its role in vertebrate embryo development remains unresolved. To address this, we deleted Smad4 in zebrafish and investigated the consequences of this on signaling by the TGF-β family morphogens, BMPs and Nodal. We demonstrate that in the absence...
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Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways
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TN_cdi_doaj_primary_oai_doaj_org_article_c3a7ce8f93434e77b3526dc4eb45c12f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c3a7ce8f93434e77b3526dc4eb45c12f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26486-3
